The Long-Term Effects of Lysine and Arginine Oligopeptide in Morganna’s Bijou Serum on Menopausal Skin (2025)

As we age, our skin undergoes significant changes influenced by both intrinsic and extrinsic factors. For menopausal women, these changes can accelerate due to hormonal shifts, leaving the skin thinner, drier, and more prone to wrinkles.

Understanding Intrinsic and Induced Skin Aging

Intrinsic Skin Aging

Intrinsic aging is a natural, chronological process driven by our genetic blueprint. This gradual and inevitable phenomenon varies from person to person but universally impacts the skin’s elasticity and firmness over time. Under an electron microscope, collagen fibers—the primary building blocks of the dermis—appear increasingly fragmented and disorganized as intrinsic aging progresses (see Figure 1). This decline in collagen quality and quantity contributes significantly to the visible signs of aging, such as fine lines, wrinkles, and sagging skin.

Induced Skin Aging

In addition to genetic factors, external influences exacerbate the aging process. These include:

  • Sun Exposure: UV radiation accelerates collagen degradation, leading to actinic aging.
  • Pollution: Environmental toxins damage skin cells and compromise the extracellular matrix.
  • Climatic Variations: Extreme weather conditions can dehydrate and stress the skin.
  • Dietary Habits: Poor nutrition can deprive the skin of essential nutrients.
  • Improper Skin Treatments: Overuse of harsh chemicals and detergents intensifies skin damage.

Protein glycation—a process where reducing sugars, such as glucose, react with proteins like collagen—further contributes to skin aging. This glycation disrupts collagen’s structure, making it rigid and less functional, which accelerates the loss of skin elasticity.

The Role of L-Lysine and L-Arginine Oligopeptide in Skin Health

Renewing the Extracellular Matrix

The extracellular matrix (ECM), located beneath the epidermis, is a connective tissue composed of fibroblasts and essential components like collagen and glycosaminoglycans. Lysine and arginine oligopeptide stimulate the renewal of these critical ECM compounds:

  1. Collagen Synthesis:
    • Collagen I: Enhances skin’s structural integrity.
    • Collagen III: Restores skin elasticity and smoothness.
    • Collagen V: Improves dermal cohesion.
  2. Glycosaminoglycan Synthesis: Supports hydration and skin plumpness by improving the water-binding capacity of the ECM.The Long-Term Effects of Lysine and Arginine Oligopeptide in Morganna’s Bijou Serum on Menopausal Skin (1)

Protecting Collagen from Degradation

Collagen degradation is primarily caused by metalloproteinases (MMP1) enzymes, which break down collagen fibers over time. L-arginine and L-lysine act as inhibitors of these enzymes, preserving the skin’s collagen reserves and maintaining its structural framework.

Inhibiting Anarchic Cross-Linking of Collagen

By acting as a biological trap, the peptide prevents anarchic cross-linking, a process that makes collagen fibers rigid and dysfunctional. This protective action ensures that collagen retains its elasticity and flexibility, critical for youthful-looking skin.

Clinical Evidence Supporting the Efficacy of Lysine and Arginine Oligopeptide

Clinical In Vitro Trial Protocol

  1. Normal human dermal fibroblasts were inoculated in 96-well plates at 37°C and 5% CO2.
  2. Upon reaching confluence, the culture medium was replaced with fresh medium containing either the test product (0.4% PEPTISKIN®) or the reference molecule (10-7 M dexamethasone).
  3. After 24 hours of incubation, the medium was replaced with an irradiation buffer. One series of plates was exposed to UVA rays (15 J/cm2), while another series was protected from light.
  4. Following irradiation, the buffer was replaced with fresh medium containing the test product or reference molecule.
  5. Plates were incubated for an additional 24 hours at 37°C and 5% CO2.
  6. Each experimental condition was conducted in triplicate.
  7. MMP1 levels were measured using a specific ELISA kit (human BIOTRACK MMP-1 – Amersham RPN2610).
  8. Cell viability was evaluated via the MTT method.

Key Findings

  1. Effect on Collagen I Synthesis

  2. s: Demonstrated a 50% increase in synthesis of non-excreted Collagen I.

  3. Effect on Collagen III Synthesis: Showed an 88% increase in synthesis, enhancing skin elasticity.

  4. MMP1 Inhibition:
    • 53% reduction in basal MMP1 levels associated with chronological aging.
    • 12% reduction in MMP1 levels induced by UV exposure.

Long-Term Benefits for Menopausal Skin

The lysine and arginine oligopeptide in Morganna’s Bijou Serum delivers significant anti-aging effects over time:

  1. Enhanced Skin Density and Firmness: By stimulating collagen production and protecting against degradation, the peptide improves skin’s structural resilience.
  2. Improved Hydration: The boost in glycosaminoglycan synthesis ensures long-lasting hydration, combating dryness associated with menopausal skin.
  3. Reduced Wrinkle Depth: Regular use smooths fine lines and wrinkles, restoring a youthful appearance.
  4. Protection Against Environmental Stressors: By safeguarding collagen and the ECM, the peptide helps the skin withstand external aggressors like UV rays and pollution.
  5. Accelerated Skin Healing: L-lysine’s role in collagen synthesis and nerve tissue regeneration supports quicker recovery from micro-damages.
  6. The Long-Term Effects of Lysine and Arginine Oligopeptide in Morganna’s Bijou Serum on Menopausal Skin (2)The Long-Term Effects of Lysine and Arginine Oligopeptide in Morganna’s Bijou Serum on Menopausal Skin (3)

Conclusion

The bio-intelligent peptide formed by L-lysine and L-arginine oligopeptide is a groundbreaking ingredient for menopausal skin care. With its triple-action benefits—renewing the extracellular matrix, protecting collagen, and preventing its cross-linking—this peptide addresses the root causes of both intrinsic and extrinsic aging. Morganna’s Bijou Serum harnesses this powerful ingredient to deliver long-term, visible improvements, offering a beacon of hope for those navigating the challenges of menopausal skin.

Invest in science-backed skincare that not only revitalizes but also protects your skin for years to come. Your journey to healthier, more youthful skin starts here.

HERE IS A LINK TO TRY OUT THIS AMAZING SERUM: https://www.morgannasalchemy.com/product/bijou/

The Long-Term Effects of Lysine and Arginine Oligopeptide in Morganna’s Bijou Serum on Menopausal Skin (2025)
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